Neuroscience 2003 Abstract
| Presentation Number: | 599.2 |
|---|---|
| Abstract Title: | Alterations in limbic and basal ganglia Fos expression after Intra-ventral pallidal NMDA in a rat model of parkinsonism. |
| Authors: |
Turner, M. S.*1,2
; Mackie, A. R.1
; Gray, T. S.2,3
; Napier, T. C-.1,2
1Dept. Pharmacol., Loyola Univ. Med. Ctr., Maywood, IL 2Neurosci. Prog., Loyola Univ. Med. Ctr., Maywood, IL 3Dept. Cell. Biol. Neurobiol. and Anat., Loyola Univ. Med. Ctr., Maywood, IL |
| Primary Theme and Topics |
Motor Systems - Basal Ganglia -- Anatomy |
| Secondary Theme and Topics | Motor Systems<br />- Basal Ganglia<br />-- Cell discharge |
| Session: |
599. Basal Ganglia: Dopamine Depletion II Poster |
| Presentation Time: | Tuesday, November 11, 2003 9:00 AM-10:00 AM |
| Location: | Morial Convention Center - Hall F-I, Board # G99 |
| Keywords: | PARKINSON, NMDA, FOS, BASAL GANGLIA |
We assessed changes in neuronal circuitry following NMDA-induced activation of the ventral pallidum (VP) and how these changes are altered in a rat model of Parkinson’s disease (PD). The model was created by a unilateral injection of 6-OHDA into the substantia nigra (SN) of rats which caused a 95% reduction in ipsilateral striatal dopamine (DA) 21- 27 days later. We previously showed that intra-VP NMDA (0.45μg/0.5μl PBS) increased the number of Fos-immunoreactive (ir) neurons in the VP and medial subthalamic nucleus (mSTN) in non-lesioned rats. This enhancement was reduced in the mSTN of the lesioned hemisphere in the PD model (SFN Abstr. 27: 430.13, 2001). The present study compared several limbic and basal ganglia outputs of the VP and the medial and lateral subfields of the STN.
Intra-VP NMDA elevated the number of Fos-ir cells in the frontal (motor) cortex and the medial substantia nigra pars reticulata (mSNpr) as well as the mSTN. This occurred in unlesioned control rats as well as in the hemisphere contralateral to the 6-OHDA treatment in lesioned rats. DA depletions reduced the number of activated cells in the mSNpr and the basolateral amygdala as well as mSTN. Thus, the influence of the VP on basal ganglia and limbic structures is reduced ipsilateral to unilateral lesions of SN DAergic neurons.
Unexpectedly, the ability of intra-VP NMDA to activate Fos-ir in the motor cortex and the lateral STN was increased in the hemisphere contralateral to 6-OHDA, as compared to non-lesioned rats. These findings suggest that long-term DA deafferentation induces a circuit “rewiring” such that the contralateral influences of VP outputs are enhanced. These findings may aid in understanding the non-motor symptoms of PD as well as the bilateral improvements seen following unilateral deep brain stimulation in PD.
Intra-VP NMDA elevated the number of Fos-ir cells in the frontal (motor) cortex and the medial substantia nigra pars reticulata (mSNpr) as well as the mSTN. This occurred in unlesioned control rats as well as in the hemisphere contralateral to the 6-OHDA treatment in lesioned rats. DA depletions reduced the number of activated cells in the mSNpr and the basolateral amygdala as well as mSTN. Thus, the influence of the VP on basal ganglia and limbic structures is reduced ipsilateral to unilateral lesions of SN DAergic neurons.
Unexpectedly, the ability of intra-VP NMDA to activate Fos-ir in the motor cortex and the lateral STN was increased in the hemisphere contralateral to 6-OHDA, as compared to non-lesioned rats. These findings suggest that long-term DA deafferentation induces a circuit “rewiring” such that the contralateral influences of VP outputs are enhanced. These findings may aid in understanding the non-motor symptoms of PD as well as the bilateral improvements seen following unilateral deep brain stimulation in PD.
Supported by USPHSG #MH45180.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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