Neuroscience 2001 Abstract
| Presentation Number: | 668.13 |
|---|---|
| Abstract Title: | CANNABINOID RECEPTOR mRNA EXPRESSION PATTERN IN HUMAN ADULT AND FETAL BRAIN. |
| Authors: |
Wang, X.*1
; Dow-Edwards, D.2
; Keller, E.3
; Guillaume, A.1
; Hurd, Y. L.1
1Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden 2Dept. Pharmacology, SUNY Health Sci. Ctr at Brooklyn, Brooklyn, NY 3Dept Forensic Medicine, Semmelweis Univ., Budapest, Hungary |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Opioids and others |
| Secondary Theme and Topics | Development<br />- Development of Sensory, Motor and Limbic Systems<br />-- Limbic system |
| Session: |
668. Addiction and drugs of abuse: opioids and others VI Poster |
| Presentation Time: | Tuesday, November 13, 2001 1:00 PM-2:00 PM |
| Location: | Exhibit Hall AAA-45 |
| Keywords: | cannabis, development, basal ganglia, amygdala |
Marijuana (Cannabis sativa) is the most widely used illicit drug in many western countries and has long been recognized as a centrally acting cannabinoid with wide spread effects on motor and cognitive functions. To date, two types of cannabinoid receptor (Cb) have been cloned, central type (Cb1) and peripheral type (Cb2). To better understand the potential effects of cannabis on the mature and developing human brain, we characterized the expression of Cb1 mRNA in normal adult and fetal brain sections. In situ hybridisation histochemistry was used to study the mRNA distribution on human brain cryosections. In adult brains, Cb1 mRNA was highly expressed throughout in the neocortex predominantly in layer II/III. The Cb1 mRNA expression was evident in scattered cells throughout the amygdala. In the striatum, homogenous high Cb1 mRNA was also expressed in the caudate and putamen with no patch/matrix compartmentalization pattern. Weak to moderate expression was observed in other regions, e.g., the mediodorsal thalamus and pallidum. In 20 weeks old fetal brains, Cb1 mRNA showed an increasing gradient of expression from lateral to medial area in the caudate and putamen with a patchy pattern of organization. Very high mRNA expression was detected in the amygdala and hippocampus. Cb2 mRNA expression was not detectable in either the fetal or adult brain. These current results show that the Cb1 mRNA is mainly localized in human brain areas associated with control of motor and cognitive function and with modulation of emotion and that there are differences between the expression of the Cb1 mRNA in the developing and mature human brain.
Supported by NIH DA12030
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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