Neuroscience 2001 Abstract
| Presentation Number: | 668.12 |
|---|---|
| Abstract Title: | THE EFFECTS OF ACUTE STRESS, AMPHETAMINE SENSITIZATION AND DOSE RESPONSE TIME ON CONDITIONED PLACE PREFERENCE TO MARIJUANA. |
| Authors: |
Young, L. E.*1
; Chin-Quee, K. P.1
1Basic Med Sci , Univ West Indies, Kingston , Jamaica |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Opioids and others |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Associative, nonassociative and skill learning & memory systems |
| Session: |
668. Addiction and drugs of abuse: opioids and others VI Poster |
| Presentation Time: | Tuesday, November 13, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall AAA-45 |
| Keywords: | ADDICTION, ANIMAL MODEL, DRUG ABUSE, REWARD |
Marijuana shares similar properties with ethanol, nicotine and phencyclidine, drugs which can produce addiction in humans, but generally do not elicit reward behavior in animals. Marijuana often elicits conditioned place aversion in animals. Also, the effect of stress on marijuana use/abuse is an area that is virtually ignored. In our experiments, development of marijuana place preference to dose-time response variations, amphetamine (amp) sensitization and different stressors (isolation, swimming, restraint) was examined. Preconditioning preferences of Wistar rats were determined in a 3-chambered box, with black and white compartments (30x 30x 15) separated by a central neutral compartment (15x 30x 15). Increased spontaneous motor activity (SMA)determined the dose of marijuana that was stimulatory (CS) and the duration of the response. Rats were treated i.p. with CS or saline and subjected to an 8-day place preference-conditioning paradigm, with confinement times of either 18 min (6 rats) or 40 min (6 rats) to the CS-paired box. Amp sensitization (3 mg/kg, i.p., n=6)or stressor was carried out for 14 days and 10 min, respectively, prior to an 18-min confinement conditioning. The 40-min period resulted in significant place aversion to marijuana (p<0.015); whereas, the 18-min period produced a neutral response (p=0.2). Amp sensitization increased marijuana preference (p=0.09); swimming had no effect, whereas, restraint increased preference (p=0.07) and isolation produced a significant preference for marijuana. Conditioned place preference to marijuana can thus develop after acute stress or a period of drug sensitization.
Supported by Mona Campus Research Fellowship Grant
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
Copyright © 2001-2025 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
