Neuroscience 2001 Abstract
| Presentation Number: | 667.11 |
|---|---|
| Abstract Title: | Nicotine withdrawal syndrome: behavioral distress and selective up-regulation of the cAMP pathway in the amygdala. |
| Authors: |
Tzavara, E. T.*1,2
; Monory, K.1
; Rodriguez, D. E.2
; Hanoune, J.1
; Nomikos, G. G.2
1INSERM U99, Creteil, France 2Neurosci Disc Res, Eli Lilly & Co, Indianapolis, IN |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Addiction and Drugs of Abuse -- Opioids and others |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- Intracellular Signalling Pathways<br />-- Second messengers |
| Session: |
667. Addiction and drugs of abuse: opioids and others V Poster |
| Presentation Time: | Tuesday, November 13, 2001 3:00 PM-4:00 PM |
| Location: | Exhibit Hall AAA-27 |
| Keywords: | ABSTINENCE, ADENYLATE CYCLASE, DRUG ABUSE, PLASTICITY |
Drug dependence and withdrawal have been associated with region specific modifications of the responsiveness of the cAMP pathway. Chronic morphine increases the expression of adenylyl cyclase (AC), especially of isoforms regulated by calcium/calmodulin, an effect unmasked during naloxone precipitated opioid withdrawal. We have reported a similar regulatory role of the cAMP pathway in SR141716A precipitated Δ9-tetrahydrocannabinol withdrawal. We have previously described a mecamylamine precipitated nicotine withdrawal syndrome that is associated with a decrease in dopamine release in the n.accumbens and the amygdala and with a selective increase of c-fos in the amygdala. In the present study we examined if behavioral manifestations of nicotine withdrawal are associated with changes in the activity of the cAMP pathway. After precipitation of nicotine withdrawal, animals were tested in an open field for locomotor activity (LMA). Nicotine withdrawn animals spent more time in the periphery of the arena, a behavior indicative of stress-related response, although their global LMA was not affected. In the same animals, AC activity was increased in a brain region selective manner. Specifically, in the amygdala, basal, forskolin stimulated and most importantly calcium/calmodulin stimulated AC activities were increased by 30% in nicotine withdrawn animals, whereas no difference was found in the n.accumbens, striatum, hippocampus and cerebellum. These adaptive changes of the cAMP pathway in the amygdala could be an important component of the behavioral distress characterizing nicotine withdrawal.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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