Neuroscience 2002 Abstract
| Presentation Number: | 677.20 |
|---|---|
| Abstract Title: | Hippocampal CA1 Spatial Representation for Snap-Shot Memory Requires CA3 NMDA Receptors. |
| Authors: |
Nakazawa, K.*1
; Wilson, M. A.1
; Tonegawa, S.1
1Ctr For Learning and Memory, Massachusetts Inst Technol, Cambridge, MA |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Learning & memory: Physiology and imaging |
| Secondary Theme and Topics | Cognition and Behavior<br />- Animal Cognition and Behavior<br />-- Associative, nonassociative and skill learning & memory systems |
| Session: |
677. Animal cognition and behavior: learning and memory--physiology and imaging: spatial processing Poster |
| Presentation Time: | Wednesday, November 6, 2002 11:00 AM-12:00 PM |
| Location: | Hall A2-B3 P-15 |
| Keywords: | PLACE CELLS, TETRODE, HIPPOCAMPUS, WORKING MEMORY |
We have studied spatial memory in genetically engineered mice with CA3 pyramidal cell ablation of the NMDA receptor subunit 1 (CA3-NR1 KO mice) (Nakazawa et al., 2000, SFN abstr. 564.3). We previously discovered that these mice were unable to remember novel locations of a hidden platform in a delayed matching-to-place version of water maze task. This deficit disappeared when familiar locations were used, suggesting that the animals relied on long-term memory to solve this short-term memory task (Nakazawa et al., 2001, SFN abstr. 744.2). Here we show, by in vivo CA1 place cell recording in familiar and novel linear tracks, that CA1 place cell activities of CA3-NR1 KO mice were enhanced and that their place fields were less confined when the mice explored a novel track. The CA1 spatial representation was restored when these mice explored the same track the following day. The CA1 place cell activities were also enhanced while the mice explored a novel open field. Once again, the activities were not enhanced the following day. These results suggest that CA3 NR-dependent neuronal networks are required for fast acquisition of new spatial representation for snap-shot memory.
Supported by NIH grant RO1 NS32925
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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