Neuroscience 2001 Abstract
| Presentation Number: | 67.19 |
|---|---|
| Abstract Title: | MULTISECOND PERIODICITIES IN NEURONAL ACTIVITY REVEAL EFFECTS OF DOPAMINE (DA) ON FUNCTIONAL CONNECTIVITY BETWEEN GLOBUS PALLIDUS (GP) AND HIPPOCAMPUS (HP) AND MOTOR CORTEX (MCX). |
| Authors: |
Bergstrom, D. A.*1
; Ruskin, D. N.1
; Tierney, P. L.1
; Walters, J. R.1
1Experimental Therapeutics Branch, NINDS, NIH, Bethesda, MD |
| Primary Theme and Topics |
Motor Systems - Basal Ganglia -- Physiology |
| Session: |
67. Basal ganglia: physiology II Poster |
| Presentation Time: | Sunday, November 11, 2001 10:00 AM-11:00 AM |
| Location: | Exhibit Hall FF-5 |
| Keywords: | basal ganglia, oscillations, theta rhythm, field potential |
Multisecond oscillations (mean: 20 - 30 sec) in neuronal firing rates in GP, substantia nigra pars reticulata, subthalamic and thalamic reticular nuclei in immobilized rats are robustly modulated by DA. These oscillations in firing rate are also correlated with bursts of transcortical EEG (tEEG) theta (4 - 7 Hz) rhythm (SFN 26: 960, 962). GP firing rate periodicities do not correlate with the tEEG theta rhythm itself, but with the multisecond periodicities in theta power. To explore the source of the correlated tEEG theta signal, localized field potentials in the HP and MCX were recorded simultaneously with GP unit activity. Dorsal HP field potentials exhibited bursts of theta power that correlated with multisecond oscillations in GP firing rates (12/23). MCX field potentials infrequently showed this correlation (4/23). Following DA agonist administration, the incidence of correlated oscillations in GP firing rate and HP theta bursts remained high (13/18) and the power of these oscillations was significantly increased. DA agonists significantly increased the incidence (11/16) of GP/MCX correlations; however, theta power and the power of multisecond oscillations in theta were relatively low in MCX both before and after DA agonists. Subsequent haloperidol administration dramatically blocked all correlations (n=10). The data reveal an unexpected close relationship of GP and HP neuronal activity on multisecond time scales, and show that DA receptor stimulation strengthens this functional connectivity between motor and limbic systems.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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