Neuroscience 2001 Abstract
| Presentation Number: | 657.7 |
|---|---|
| Abstract Title: | A Functional MRI STUDY OF TWO STROOP VARIANT TASKS IN HIV-INFECTED INDIVIDUALS. |
| Authors: |
Searl, M. M.*1
; Bush, G.2
; Stern, C. E.1,2
1Psychology, Boston University, Boston, MA 2NMR Center, Massachusetts General Hospital, Charlestown, MA |
| Primary Theme and Topics |
Neurological and Psychiatric Conditions - Neuroimmunology and Infections |
| Secondary Theme and Topics | Cognition and Behavior<br />- Human Cognition and Behavior<br />-- Attention |
| Session: |
657. Neuroimmunology and infections: infection--prions and HIV Poster |
| Presentation Time: | Tuesday, November 13, 2001 3:00 PM-4:00 PM |
| Location: | Exhibit Hall XX-51 |
| Keywords: | AIDS, FMRI, ATTENTION, CORTEX |
Converging lines of evidence suggest that the Human Immunodeficiency Virus (HIV) can cause frontal-subcortical damage and cognitive dysfunction. Neuropsychological studies have demonstrated sensitivity of the Stroop Interference Task to HIV-related cognitive dysfunction, but the underlying pathophysiology is poorly understood. In this study, fMRI (1.5T Siemens, TR=2, 21 slices of 5 mm, blocked design, SPM '99) was used to compare patterns of brain activity in 9 HIV-positive (HIV+) and 8 HIV-negative (HIV-) males during performance of two Stroop-variant tasks. In the Counting Stroop (Bush '98), subjects used a button-press to indicate the number of animal names (neutral) or incongruent number words (interference) presented on a screen. HIV+ subjects were slower and more susceptible to interference than HIV- subjects. FMRI analysis (interference vs. neutral) showed that HIV+ subjects also recruited more regions of motor and parietal cortex compared to HIV- subjects. In the Oddball Stroop (Bush, personal communication), subjects used a button-press to identify a target number (1,2, or 3) when it was shown with two X s (control) or among a pair of non-target numbers (interference). Again, HIV+ subjects were slower and more susceptible to interference than HIV- subjects. FMRI analysis (interference vs. control) revealed that HIV+ subjects also recruited more thalamic, pre-motor and inferior frontal regions while HIV- subjects showed greater prefrontal and posterior parietal activity. These findings suggest that fMRI may be a useful tool in elucidating the neural substrate of cognitive dysfunction in HIV.
Supported by RO1 NS40239-01 (CES, MMS), NIMH01611 (GB), NARSAD (GB)
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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