Neuroscience 2004 Abstract
| Presentation Number: | 595.7 |
|---|---|
| Abstract Title: | Activation of the left anterior inferior frontal gyrus after melodic intonation therapy in a Broca’s aphasia patient. |
| Authors: |
Overy, K.*1
; Norton, A. C.1
; Ozdemir, E.1
; Helm-Estabrooks, N.2
; Schlaug, G.1
1Neurol., Harvard Med. Sch., Boston, MA 2MA, Beth Israel Deaconess Medical Center, 02215, |
| Primary Theme and Topics |
Cognition and Behavior - Human Cognition, Behavior, and Anatomy -- Language |
| Session: |
595. Language IV Slide |
| Presentation Time: | Tuesday, October 26, 2004 9:30 AM-9:45 AM |
| Location: | San Diego Convention Center - Room 5B |
| Keywords: | Language, Music |
The designers of Melodic Intonation Therapy (MIT) have hypothesized that the method’s therapeutic benefits to non-fluent aphasic patients are due to a gradual recruitment of right hemispheric language regions for the production of speech. In order to examine such potential neural plasticity effects, we used functional magnetic resonance imaging (fMRI) to examine the neural basis of spoken and melodically intoned words in a severely non-fluent aphasic patient both pre and post 4 weeks of MIT.
Images were acquired on a 3T GE MRI scanner, using a sparse temporal sampling technique that takes advantage of the inherent delay in the cerebrovascular response to neural activity. Whole-brain acquisitions (taking 1.75s) were conducted every 15 seconds, immediately after each vocalization, thus avoiding maximum head movement artefacts and also avoiding any scanner noise interference with the stimuli presentation and recording of the vocalizations. Four different experimental conditions were employed: spoken words, melodically intoned words, hummed syllables and ‘phonation’ (“ah”). The patient (male, age 29,10 years post a middle cerebral artery stroke), heard each bi-syllabic phrase over headphones and imitated on cue. In a silence condition, the patient simply took a breath on cue.
Pre-processing and analysis was conducted using SPM99. The most striking results were revealed in the contrasts between the speaking and phonation conditions. Pre-therapy, the patient exhibited only slight activation during speech compared to phonation, in the right supramarginal gyrus and the left angular gyrus. Post-therapy, and with improved speech production, the patient exhibited significant activation in the left anterior inferior frontal gyrus. Such results suggest that brain regions surrounding a lesion may be important for the recovery of impaired function after stroke.
Images were acquired on a 3T GE MRI scanner, using a sparse temporal sampling technique that takes advantage of the inherent delay in the cerebrovascular response to neural activity. Whole-brain acquisitions (taking 1.75s) were conducted every 15 seconds, immediately after each vocalization, thus avoiding maximum head movement artefacts and also avoiding any scanner noise interference with the stimuli presentation and recording of the vocalizations. Four different experimental conditions were employed: spoken words, melodically intoned words, hummed syllables and ‘phonation’ (“ah”). The patient (male, age 29,10 years post a middle cerebral artery stroke), heard each bi-syllabic phrase over headphones and imitated on cue. In a silence condition, the patient simply took a breath on cue.
Pre-processing and analysis was conducted using SPM99. The most striking results were revealed in the contrasts between the speaking and phonation conditions. Pre-therapy, the patient exhibited only slight activation during speech compared to phonation, in the right supramarginal gyrus and the left angular gyrus. Post-therapy, and with improved speech production, the patient exhibited significant activation in the left anterior inferior frontal gyrus. Such results suggest that brain regions surrounding a lesion may be important for the recovery of impaired function after stroke.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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