Stress is a significant risk factor for a multitude of mental, cardiovascular, metabolic, and immune diseases. Cannabis users report stress relief as their primary reason for use, although studies have found a positive relationship between cannabis use ...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

In an age of readily available digital information - and misinformation - it is essential for the scientific community to take an active role in communicating with the public. Key topics such as stem cell biology, gene editing, traumatic brain injury an...

Increasing evidence supports the idea of a beneficial effect of cannabinoid compounds for the treatment of multiple sclerosis (MS). However, most experimental data come from animal models of MS. We investigated the status of cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase (FAAH) enzyme in brain tissue samples obtained from MS patients. Areas of demyelination were identified and classified as active, chronic, and inactive plaques. CB1 and CB2 receptors and FAAH densities and cellular sites of expression were examined using immunohistochemistry and immunofluorescence. In MS samples, cannabinoid CB1 receptors were expressed by cortical neurons, oligodendrocytes, and also oligodendrocyte precursor cells, demonstrated using double immunofluorescence with antibodies against the CB1 receptor with antibodies against type 2 microtubule-associated protein, myelin basic protein, and the platelet-derived growth factor receptor-α, respectively. CB1 receptors were also present in macrophages and infiltr...

Tau is a microtubule binding protein giving structural support to neurons and facilitating axonal transport. Alternative tau mRNA splicing results in the tau isoforms that contain exon 10 and encode four microtubule binding domains (4R) or lack exon 10 ...