Pathological tau aggregates occur in Alzheimer’s disease (AD) and other neurodegenerative tauopathies. It is not clearly understood why tauopathies vary greatly in the neuroanatomical and histopathological patterns of tau aggregation, which may contribu...

Substance abuse is a major Public Health issue, with consequences for the individual, family, and society. When substance abuse occurs during pregnancy, the offspring are also affected. Marijuana, a cannabinoid (CB)-containing botanical, is a commonly u...

Carlos Costas-Insua, Estefanía Moreno, Irene B. Maroto, Andrea Ruiz-Calvo, Raquel Bajo-Grañeras, et al. (see pages [7924–7941][1]) Endocannabinoids are produced at postsynaptic sites throughout the brain, and they act predominantly on presynaptic G-protein-coupled CB1 receptors (CB1Rs) to

Misuse of synthetic cannabinoids (SCs) continues to increase worldwide and is often associated with serious adverse effects including hallucinations, cardiovascular abnormalities, coma, or death. Many SCs are aminoalkylindole molecules that are distinct...

Cannabis-induced psychosis (CIP) represents a growing health issue and their underlying neurobiological mechanisms are poorly understood. Moreover, current antipsychotic treatments used to treat CIP are limited either by side-effects or by their ability...

Guidance molecules regulate the navigation of retinal ganglion cell (RGC) projections toward targets in the visual thalamus. In this study, we demonstrate that the G-protein-coupled receptor 55 (GPR55) is expressed in the retina during development, and regulates growth cone (GC) morphology and axon growth. In vitro , neurons obtained from gpr55 knock-out ( gpr55-/- ) mouse embryos have smaller GCs, less GC filopodia, and have a decreased outgrowth compared with gpr55+/+ neurons. When gpr55+/+ neurons were treated with GPR55 agonists, lysophosphatidylinositol (LPI) and O-1602, we observed a chemo-attractive effect and an increase in GC size and filopodia number. In contrast, cannabidiol (CBD) decreased the GC size and filopodia number inducing chemo-repulsion. In absence of the receptor ( gpr55-/- ), no pharmacologic effects of the GPR55 ligands were observed. In vivo , compared to their wild-type (WT) littermates, gpr55-/- mice revealed a decreased branching in the dorsal terminal nucleus (DTN) and a lower...

In a ten-year period (2005-2015), there has been a 5% decrease in traditional cigarette smokers and a significant increase in the number of people using Electronic nicotine delivery systems (ENDs) and Electronic-cigarettes (E-cigs) in the United States....

Two types of cannabis oils are used by humans - hash oil and hemp oil. Hash oil is an oleoresin extracted from the buds, flowers and leaves of female marijuana, while hemp oil is extracted from the seeds of the hemp plants. Since hash oil contains highe...

Highlighted Research Paper: [[Cannabinoid Signaling Recruits Astrocytes to Modulate Presynaptic Function in the Suprachiasmatic Nucleus. Lauren M. Hablitz, Ali N. Gunesch, Olga Cravetchi, Michael Moldavan and Charles N. Allen][2]. ][2] []: /lookup/doi/10.1523/ENEURO.0081-19.2020

Cannabis use is common among pregnant women and during the pre-conception period (up to 22%); however, prenatal cannabis use may have detrimental effects on childhood outcomes, including neurodevelopment. Indeed, research shows that constituents of cann...