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AbstractWe recorded the activity of dorsolateral prefrontal cortex (PFdl) neurons in two rhesus monkeys performing saccades from a central fixation point to either a remembered or an attended location. A peripheral light spot appeared at one location (0, 90, 180, or 270°), which the monkey had to remember, and then rotated to a new location, which the monkey had to attend to in order to detect a subtle luminance change. Brightening of the light spot instructed a saccade to its initial (remembered) location while dimming instructed a saccade to its current (attended) location. Our previous analysis (Lebedev et al., SFN Abstracts, 2002) showed that, prior to the luminance change, more PFdl neurons encoded the attended location than the remembered one (64% to 17%). The present analysis focused on trials on which the spot dimmed and the monkeys correctly made a saccade to the spot’s current (attended) location. The perisaccadic activity of 498 PFdl neurons was tuned for the spot’s location (ANOVA, p≦0.05). We compared...Nov 11, 2003