Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), and Parkinson’s Disease (PD), including PD with mild cognitive impairment (MCI) and dementia, are all characterized by parkinsonian motor features that may additionally include cogni...

Cannabis Sativa has been used in folk medicine to treat pain, gastrointestinal disturbances, depression and other conditions. Cannabis also has undesirable effects such as memory impairment and hyperphagia. Tetrahydrocannabinol, a psychoactive terpenoid...

The lateral habenula (LHb) is a brain region implicated in coordinating behavioral responses to punishment, omission of reward, and other negative environmental stimuli. Moreover, LHb neurons increase their activity during behavioral avoidance and in de...

CB1 cannabinoid receptors are G-protein coupled receptors enriched on presynaptic processes in several central nervous system regions including those that underlie analgesia, cognition, motor control, and memory. CB1 receptors are the primary target of delta-9-tetrahydrocannabinol, (THC) the major psychoactive constituent of cannabis, and are also activated by endogenous cannabinoids. Tolerance develops following chronic THC use and CB1 receptor internalization is a process likely to contribute to tolerance. It is known that following sustained agonist treatment, heterologously expressed CB1 receptors internalize via a classical clathrin-mediated pathway. The aim of this study was to develop and characterize a technique to investigate the kinetics and mechanisms of CB1 internalization in primary hippocampal cultures using immunocytochemistry and confocal microscopy. During brief administration of the synthetic CB1 agonist CP55,940, CB1 staining in boutons became increasingly punctuate. This was quantified ...

Here we addressed the hypothesis that L-DOPA-induced dyskinesia (LID) could be favored by the striatal pro-inflammatory environment resulting from abnormal glutamate (GLU) release from the motor cortex induced by L-DOPA dyskinesiogenic treatment. To thi...

The use of cannabis during pregnancy is a growing public health concern. Unfortunately, as the cannabis industry has been rapidly expanding, research on the effects of cannabis use during pregnancy remains limited and the effects of maternal cannabis us...

Cannabis is the most used illicit drug during pregnancy, yet little is known about the lasting impacts of prenatal cannabis exposure on neurodevelopmental endpoints. To address this issue, our laboratory recently used a novel cannabis vapor exposure mod...

Some pregnant women use cannabis to assuage symptoms of morning sickness or anxiety, and some cannabis-using women may have not known they were pregnant. However, research shows that approximately 1/3 of cannabis constituents, such as delta-9-tetrahydro...

Glycine and type A γ-aminobutyric acid receptors (GlyRs and GABAARs) are ligand-gated ion channels that mediate fast inhibitory neurotransmission in the nervous system. Direct modulation of GlyRs and GABAARs by a number of cannabinoids has been previous...

There is an overdose epidemic associated with the use of illicitly manufactured as well as prescription mu-opioid agonists. Sigma1 receptor (σ1R) antagonists in combination with other drugs may provide a viable, safe pharmacological option for treating ...