Description of neuroimmune responses in physiological rather than psychological, social, forensic concepts of chronic problems after mild head trauma (LeFever, INS 1995) was extended and applied to mental fatigue(LeFever SFN 1996) and stress responses transiently exceeding compensation for low prefrontal and basal ganglia dopamine resources as a basis for typical sporadic exacerbation (LeFever SFN 1998). In this update, to restore unity of motivation, attention, and action seen in old studies of hypothalamic facilitation of goal directed behavior, lost in current specialized research, and account for increased subjective sense of effortful initiation poorly labeled fatigue, we intended introducing a new concept, central fatigue at ventromedial rather than traditional dorsolateral sites, but found it well developed by Chaudhuri & Behan (J. Neurol. Sci. 2000,179: 34-42). Our updates include: antigenic & inflammatory aspects of axonal disruption, beyond brain mast cell activation by myelin basic protein (LeFe...