Brain aging is accompanied by a number of cellular and molecular changes that may ultimately lead to cognitive deficits. One of these changes is a decline in the activity of the endocannabinoid system characterised by diminished 2-arachidonoylglycerol l...

Sustained cannabis consumption during adolescence has been widely associated to cognitive impairments and enhanced risks for anxiety/mood disorders at adulthood. In particular, clinical and preclinical evidence has demonstrated that chronic exposure to ...

Introduction: Limited therapeutic effects of current Alzheimer (AD) treatments highlight the need for new research approaches. Drugs that simultaneously target different aspects of AD could provide therapeutic benefits. Targeting the endocannabinoid sys...

Cannabis is one of the most frequently used illicit drugs worldwide, and has been banned in the United States and Canada since the early 1900s. A recent United Nations report places cannabis at the top of the 2010 illicit drug use list, at an estimated ...

Dravet Syndrome (DS) is one of the most severe childhood neuropsychiatric diseases, with intractable epilepsy, febrile seizures developmental delay, ataxia, sleep disorder, autistic-like behaviors, frequent premature death and profound cognitive deficit...

Cannabidiol microinjected into basolateral amygdaloid complex does not modifiy anxiety-like behavior in the elevated plus maze. Lisboa, S.F.S.; Guimarães, F.S. Pharmacology Department, Faculty of Medicine of Ribeirão Preto, FMRP/USP, Ribeirão Preto - Sã...

Intoxicating tetrahydrocannabinol (THC) and non-intoxicating cannabidiol (CBD) are the two most prevalent phytocannabinoids found in cannabis sativa plants. CBD is well studied in multiple disease models, especially as anti-convulsant in treatment of in...

Δ9-tetrahydrocannabinol (THC) is the principal psychoactive constituent of marijuana or cannabis. The major effect of THC is mainly mediated by cannabinoid CB1 receptors (CB1Rs). THC produces both rewarding and aversive effects in experimental animals. ...

Cannabidiol (CBD) is a non-intoxicating phytocannabinoid with rapidly escalating popularity for the treatment of numerous off-label conditions including pain, anxiety, depression, hyperactivity, and autism spectrum disorder. Since CBD consumption is gen...

MDMA (Ecstacy) is a drug that is widely used by young people in many countries. There is increasing evidence that heavy use of MDMA damages brain serotonin (5-HT) systems, leading to chronic emotional and cognitive problems. We have shown that male Wistar rats briefly exposed to MDMA (4 x 5 mg/kg i.p. over four hours on each of two days) show long term increases in anxiety-like behavior three months after MDMA exposure (Morley et al EJP (2001) 433, 91-99). Human MDMA users frequently consume cannabis while under the influence of MDMA and the present study examined whether this might modulate the long term behavioral and neurotoxic effects of MDMA in rats. The active constituent of cannabis Δ9-THC (4 x 2.5 mg/kg over 4 h) reversed the acute hyperthermic effects of MDMA (4 x 5 mg/kg) on each of two days of administration, with rats given the MDMA/THC combination showing a robust hypothermia. Six weeks later rats that had received the MDMA/THC combination were less anxious on the emergence test than rats that...