Establishing a primate multiscale genetic brain network linking key microstructural brain components to social behavior remains an elusive goal. Diffusion MRI, which quantifies the magnitude and anisotropy of water diffusion in brain tissues, offers unp...

There is growing interest in segmenting the hippocampus into subfields to determine their specific computational functions, and to assess their integrity as a biomarker for various diseases. However, limitations in MRI resolution, knowledge about subfie...

Early childhood is a critical period showing experience-dependent changes in brain structure and function. The complex link between the structural connectivity (SC) and functional connectivity (FC) of the brain is of particular interest. However, its relationship with both age and attention in early childhood is not well understood. In this study, children between the ages of 4 and 7, and at a one-year follow-up visit, underwent neuroimaging (diffusion-weighted and passive-viewing functional magnetic resonance imaging) and assessments for selective, sustained, and executive attention. We examined regional graph metrics and SC-FC coupling of the structural and functional networks. Partial least squares (PLS) was used to investigate longitudinal brain measure changes and cross-sectional associations with age and attention. We observed longitudinal changes in functional graph metrics and age-related decreases in SC modularity. Region-wise graph analyses revealed variable brain-behaviour relationships across t...

Introduction: Resting state fMRI is a trending imaging modality. It is frequently used in identifying abnormalities in brain activation either at rest or while performing a task. In resting fMRI (RfMRI), the most common analysis technique is Independent...

The frontal and the supplementary eye fields (FEF and SEF) play a major role in the cortical control of the voluntary saccades in humans but little is known about anatomical location of the parietal and cingular eye fields (PEF and CEF) in functional MRI. The aim of this study was to obtain detailed information of PEF and CEF activation during voluntary saccades. We investigated the cerebral activation during a horizontal self-paced voluntary saccade task versus central fixation in seven young adult healthy volunteers, using echo-planar fMRI in a 1.5 T scanner. Data were analyzed with SPM99. In addition to FEF and SEF activation, both individual and group analysis disclosed significant activation in two anatomically distinct areas within the cingular cortex (posterior cingular sulcus, anterior cingular sulcus) and bilaterally in three anatomically distinct areas within the parietal cortex (anterior part of the intraparietal sulcus (IPS), posterior part of the IPS, precuneus in the interhemispheric fissure)...

In MRI studies of patients with neuropathology (e.g. stroke, trauma), it is critical that the full extent of the brain lesion is identified. Typically, segmentation of the lesion from the areas without pathology is performed manually by one, sometimes t...

Autism is a heterogeneous neurodevelopmental disorder of unknown etiology and neuropathology. A recent and consistent hypothesis has emerged that young toddlers with autism undergo abnormal neuroanatomical development that includes a period of early bra...

INTRODUCTION: The severity of pathological protein deposition, and concomitant iron presence distinguishes neurological disorders. Tissues with high amounts of protein or iron deposits have a characteristically rapid T2* MRI signal decay. Therefore, the...

The parahippocampal gyrus, located in the medial temporal lobe, is a key brain area in memory processing. Several recent functional studies performed either in humans or in non human primates have revealed the implication of its rostral part, the temporal pole in declarative memory. The temporal pole is located rostral to the entorhinal and piriform cortices. We have analyzed the general organization of the temporal pole in humans from MR images and histological slices, on both, macroscopic and cytoarchitectonic aspects. This work was also performed to provide anatomical landmarks to facilitate and precise the brain structures implicated in memory as revealed by functional MRI and PET activation studies. The basic analysis has been performed from the brain of 9 healthy people. The brains were serially sectioned and stained with thionin to determine cytarchitectonic boundaries. T1-weighted MR images obtained in controls were analyzed in reference to the neighboring anatomical landmarks. The features of the ...

Walking direction (WD) can be recognized effortlessly from a point-light walker (PLW) on a treadmill without translational displacement of the body. A PLW induces illusional motion in its background in a direction opposite to WD (backscroll illusion). T...