Society for Neuroscience - Search

Skip Navigation

  • join logo Join
  • hands shaped like a yellow heart icon Give
  • advocate logo Advocate
  • publish logo Publish
  • Icon with thought bubbles Learn
Shop Sign In
SfN Logo 2025
  • Membership
    • Learn About Membership
      • Individual Member Benefits
      • Institutional Program Member Benefits
      • Sustaining Associate Member Benefits
      • Get Involved at SfN
    • Become a Member
      • Sponsorship Information for New Members
      • Membership Categories & Fees
      • Membership Fees for Developing Countries
      • Renew Individual Membership
    • Member Resources
      • Automatic Renewals
      • Frequently Asked Questions
      • Individual Member Directory
      • Member Obituaries and Memorial Donations
    • Learn About Local Chapters
      • Start or Reactivate a Chapter
      • Resources for Chapters
      • Submit Annual Report
      • Chapter Directory
      • Frequently Asked Questions
  • Meetings
    • Meetings Overview
    • Neuroscience 2025
      • Presenter Resources
      • Itinerary Planner and Mobile App
      • Sessions and Events
      • Registration
      • Housing and Travel
      • Exhibits
      • Advertising and Sponsorship
      • FAQs
    • Global Events
      • SfN Virtual Events
    • Past and Future Annual Meetings
      • Neuroscience 2024
      • Neuroscience 2023
      • Search Past Annual Meeting Abstracts
      • Attendance Statistics
    • Meeting Policies and Guidelines
      • Code of Conduct at SfN Events
      • Growth and Opportunity Strategy
      • Photography & Recording Policy
      • Presenter Guidelines and Policies for SfN Events
    • Meeting Awards
      • Trainee Professional Development Award
      • International Travel Awards
      • FENS Member Awards to SfN Annual Meeting
      • IBRO Member Awards to SfN Annual Meeting
      • JNS Member Awards to SfN Annual Meeting
  • Careers
    • Careers Overview
    • Institutional Program (IP) Directory
    • NeuroJobs Career Center
      • Job Seekers
      • Employers
    • 2025 Graduate School Fair
    • Career Tools and Resources
      • Neuronline
      • Neurobiology of Disease Workshop
      • Responsible Conduct of Research Short Courses
      • Neuroscience Departments and Program Workshop
      • Global Funding Sources
    • Higher Education and Training
      • Core Competencies
      • Neuroscience Training Program Survey
    • Awards
      • Outstanding Career and Research Achievements
      • Early Career
  • Initiatives
    • Initiatives Overview
    • Awards
      • 2024 Award Recipients
      • Awards and Prizes FAQ
      • Trainee Professional Development Award
    • Neuroscience Scholars Program
    • Neuronline
      • Webinars
      • Articles
      • Videos
      • Podcasts
      • Collections
    • Resources to Stay Connected
      • SfN Zoom Backgrounds
    • Community
    • Women and Neuroscience
      • Increasing Women in Neuroscience (IWiN) Courses & Toolkit
      • Celebration of Women in Neuroscience Event
      • Awards
    • Animals in Research
      • Support for Members and Institutions
      • Tools and Resources
      • Resources for Medical Students
    • Public Education Programs
      • Resources for Educators
      • Brain Awareness Video Contest
      • Life of a Neuron Exhibit
  • Advocacy
    • Advocacy Overview
    • Advocacy Response
    • Advocacy Network
      • The NeuroAdvocate Challenge
      • Advocacy Action Center
      • Advocacy Best Practices
      • Advocacy Network News
      • Advocacy Training Seminars
    • US Advocacy Programs
      • Capitol Hill Day
      • Connect with Policymakers
      • Early Career Policy Ambassadors
      • Partner with a Local Chapter
      • Engage the Media
    • Global Advocacy Programs
      • Global Neuroscience Initiatives
      • Global Funding
      • North American Programs
    • Science Funding
      • Advocacy Videos
      • Advocacy Resources
      • US Neuroscience Initiatives
      • Funding Priorities and Processes
    • Policy Positions
      • Statements and Testimony
      • Sign-On Letters
  • Outreach
    • Outreach Overview
    • BrainFacts.org
    • Find a Neuroscientist
    • Brain Awareness Campaign
      • Webinar: The ABC's of BAW
      • How to Get Involved
    • Awards
      • Award for Education in Neuroscience
      • Next Generation Award
      • Chapter of the Year Award
      • Science Educator Award
  • Publications
    • Publications Overview
    • SfN News
    • JNeurosci
    • eNeuro
    • SfN Nexus
    • Neuroscience Quarterly
    • Annual Report
    • History of Neuroscience Autobiographical Chapters
  • About
    • About Overview
    • Mission and Strategic Plan
    • What We Do
      • Annual Report
      • Bylaws
      • Resolutions to the Bylaws
      • Environmental Commitment
      • Strategic Partners
      • History of SfN
    • SfN 50th Anniversary Celebration
    • NIH Public Health Service-Supported Funding Financial Conflict of Interest Policy
    • Volunteer
      • SfN Council
      • SfN Presidents
      • Committees
      • Elections
      • Call for Nominations
    • Professional Conduct
      • SfN Ethics Policy
      • Guidelines for Responsible Conduct Regarding Scientific Communication
      • Code of Conduct at SfN Events
      • Commitment to Scientific Integrity
      • Neuronline Digital Learning Community Guidelines
    • History of Neuroscience
      • Autobiographical Chapters
      • Autobiographical Videos of Prominent Neuroscientists
      • Classic Papers
      • Neuroscience History Resources
      • Robert Doty's Chapter on Neuroscience
    • Careers and Staff
      • Staff List
  1. Search

Filter

  • (43)
  • (35)
  • (14)
  • (2)
  • (1)
  • (22)
  • (2)
  • (91)
  • (1)
  • (1)
  • (115)
  • (2)
  • (2)
  • (6061)
  • (72)
  • (71)
  • (96)
Filter
1691 - 1700 of 33803 results
  • Dopamine Release in the Nonhuman Primate Caudate and Putamen Depends upon Site of Stimulation in the Subthalamic Nucleus | Journal of Neuroscience
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory Parkinson's disease. Although DBS has recognized clinical utility, its biologic mechanisms are not fully understood, and whether dopamine release is a potential factor in those mechanisms is in dispute. We tested the hypothesis that STN DBS-evoked dopamine release depends on the precise location of the stimulation site in the STN and the site of recording in the caudate and putamen. We conducted DBS with miniature, scaled-to-animal size, multicontact electrodes and used functional magnetic resonance imaging to identify the best dopamine recording site in the brains of nonhuman primates (rhesus macaques), which are highly representative of human brain anatomy and circuitry. Real-time stimulation-evoked dopamine release was monitored using in vivo fast-scan cyclic voltammetry. This study demonstrates that STN DBS-evoked dopamine release can be reduced or increased by redirecting STN stimulation to...
    Jun 1, 2016 Hoon-Ki Min
  • Abstract
    Development in the Delayed Match- and Nonmatch-to-Sample Memory Tasks: An Event-Related Functional MRI Approach.
    Previous lesion research with non-human primates has demonstrated the hippocampal involvement in delayed match and non-match to sample (DMS/DNMS) tasks. Earlier functional imaging work in our laboratory with humans has found that BOLD activity in the medial temporal lobe (MTL), in particular the right hippocampus, is increased during performance of the memory task. The present study extends this line of work by investigating development of the neural correlates underlying memory on the DMS/DNMS task. The hippocampal activity of 7-12 year old children was investigated using high resolution (4 Tesla) event-related functional magnetic resonance imaging (fMRI). Results indicate that children recruit similar brain regions as adults, suggesting that at least by this age, children’s reliance on MTL structures is at or very close to adult levels.
    Nov 13, 2001
  • Abstract
    Assessment of individual differences in navigation by diffusion MRI connectometry
    Navigation is arguably one of the most important behaviors associated with survival. Although a common, optimized strategy among individuals within a species could be advantageous, in reality, navigation has an incredible degree of variability, both bet...
    Oct 21, 2019
  • Abstract
    Functional connectivity of the claustrum in humans and rats at 7T MRI
    The claustrum has reciprocal connectivity with multiple cortical networks and potentially has an important role in orchestrating activity across these functional networks. However, the claustrum’s sheet-like shape and close apposition to medially lying ...
    Nov 16, 2016
  • The White Matter Integrity and Functional Connection Differences of Fornix (Cres)/Stria Terminalis in Individuals with Mild Cognitive Impairment Induced by Occupational Aluminum Exposure | eNeuro
    Long-term aluminum (Al) exposure increases the risk of mild cognitive impairment (MCI). The aim of the present study was to investigate the neural mechanisms of Al-induced MCI. In our study, a total of 52 individuals with occupational Al exposure >10 years were enrolled and divided into two groups: MCI (Al-MCI) and healthy controls (Al-HC). Plasma Al concentrations and Montreal Cognitive Assessment (MoCA) score were collected for all participants. And diffusion tensor imaging and resting-state functional magnetic resonance imaging were used to examine changes of white matter (WM) and functional connectivity (FC). There was a negative correlation between MoCA score and plasma Al concentration. Compared with the Al-HC, fractional anisotropy value for the right fornix (cres)/stria terminalis (FX/ST) was higher in the Al-MCI. Furthermore, there was a difference in FC between participants with and without MCI under Al exposure. We defined the regions with differing FC as a “pathway,” specifically the connectivi...
    Aug 1, 2024 Feifei Zhang
  • Region-Specific Hierarchy between Atrophy, Hypometabolism, and β-Amyloid (Aβ) Load in Alzheimer's Disease Dementia | Journal of Neuroscience
    Gray matter atrophy, glucose hypometabolism, and β-amyloid Aβ deposition are well-described hallmarks of Alzheimer's disease, but their relationships are poorly understood. The present study aims to compare the local levels of these three alterations in humans with Alzheimer's disease. Structural magnetic resonance imaging, 18F-fluorodeoxyglucose positron emission tomography (PET), and 18F-florbetapir PET data from 34 amyloid-negative healthy controls and 20 demented patients with a high probability of Alzheimer's disease etiology (attested using neuroimaging biomarkers as recently recommended) were analyzed. For each patient and imaging modality, age-adjusted Z -score maps were computed, and direct between-modality voxelwise comparison and correlation analyses were performed. Significant differences in the levels of atrophy, hypometabolism, and Aβ deposition were found in most brain areas, but the hierarchy differed across regions. A cluster analysis revealed distinct subsets of regions: (1) in the hippoc...
    Nov 14, 2012 Renaud La Joie
  • Abstract
    Astrocyte-specific expression of tdp-43 during development causes blindness in 12-month-old mice
    Transactive response DNA binding protein 43 (TDP-43) is the major pathological protein in motor neuron disease. In some models of TDP-43 overexpression, mice do not survive when the transgene is on throughout normal development. We utilized an inducible...
    Nov 11, 2021
  • Abstract
    Tonotopic mapping of the mouse auditory midbrain with Mn-enhanced MRI.
    Our previous studies have established the utility of Mn-enhanced MRI (MEMRI) for detecting aggregate sound-evoked activity within the inferior colliculus (IC) of hearing and deaf mice. The present goal was to determine the spatial resolution of MEMRI by examining sound frequency-dependent patterns of activity in the mouse IC. Electrophysiological recordings have established the tonotopic map in mouse IC using threshold stimulation. However, there is little information on the spatial pattern of activity for suprathreshold stimulation. Following Mn injections, mice were exposed to one of the following acoustic stimuli in the free field at 65-89 dB SPL: wideband (1-59 kHz), high frequency band pass (20-50 kHz), or pure tones (16 or 40 kHz). Wideband stimulation elicited a diffuse pattern of IC enhancement covering most of the central nucleus, and this spatial pattern became more confined to the ventral-caudal IC with high frequency band pass stimulation. The spatial pattern resolved into a clear ventral-cauda...
    Nov 16, 2005
  • Abstract
    Mri characterisation of a novel rat model of focal astrocyte loss.
    Blood brain barrier (BBB) integrity is lost several neurological conditions in which astrocytes are damaged. We have studied the focal lesions induced by systemic injection of 3-choloropropanediol, a toxicant that induces early astrocytic (but not neuronal) death followed by BBB leakage. Anatomical images of coronal brain sections illustrate the regional selectivity of the lesions, with affected areas including symmetrical brain stem and midbrain nuclei: primarily the inferior colliculi and red nuclei. The MRI intensity in the lesioned areas peaked at 2 days post-injection, correlating with the later BBB breakdown, and diminished thereafter; returning to close to pre-injection levels by 30 days in parallel with the return of astrocytes. T2 measurements of the lesioned areas increased at 2 days indicating increased water content in the lesioned areas, consistent with cellular damage and BBB leakage. T2 was not increased at 6 hours, a time when astrocyte swelling is marked but the vasculature is intact. Inje...
    Oct 25, 2004
  • Molecular fMRI | Journal of Neuroscience
    Comprehensive analysis of brain function depends on understanding the dynamics of diverse neural signaling processes over large tissue volumes in intact animals and humans. Most existing approaches to measuring brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for well-defined neural events. Here we discuss a new brain activity mapping method that overcomes some of these problems by combining MRI with contrast agents sensitive to neural signaling. The goal of this “molecular fMRI” approach is to permit noninvasive whole-brain neuroimaging with specificity and resolution approaching current optical neuroimaging methods. In this article, we describe the context and need for molecular fMRI as well as the state of the technology today. We explain how major types of MRI probes work and how they can be sensitized to neurobiological processes, such as neurotransmitter release, calcium signaling, and gene expression changes. We comment both on past work in the field an...
    Apr 13, 2016 Benjamin B. Bartelle
  • Previous
  • 168
  • 169
  • 170
  • 171
  • 172
  • Next

Featured

  • Apply to be a Neuronline Community Leader
  • The Neuroscience Meeting Planner is Now Available!
  • Register for the #SfN25 Mentorship Workshop in San Diego
SfN Websites
  • BrainFacts.org logo
  • eNeuro logo
  • JNeurosci logo
  • Neuronline logo
Engage with SfN
  • join Join
  • give Give
  • advocate Advocate
  • publish Publish
Quick Links
  • SfN News
  • For Press
  • Global Events
  • Contact Us
  • Advertise
  • Code of Conduct
  • Jobs at SfN
  • SfN Store
  • Social Media
Follow SfN
  • BlueSky logo
  • Facebook logo
  • Instagram logo
  • LinkedIn logo

  • Threads logo
  • X Logo
  • YouTube logo
SfN logo with "SfN" in a blue box next to Society for Neuroscience in red text and the SfN tag line that reads "Advancing the understanding of the brain and nervous system"
1121 14th Street NW, Suite 1010, Washington, D.C. 20005
(202) 962-4000 | 1-888-985-9246
  • Accessibility Policy
  • Disclaimer
  • Privacy Notice
  • Contact Us

Copyright ©
Society for Neuroscience