Neuroscience 2001 Abstract
| Presentation Number: | 648.16 |
|---|---|
| Abstract Title: | Effects of Oleamide on Food Intake and Sexual Behavior. |
| Authors: |
Martinez-Gonzalez, D.*1
; Bonilla-Jaime, H.2
; Morales-Otal, A.2
; Velazquez-Moctezuma, J.2
; Navarro, L.1
; Prospero-Garcia, O.1
1Fisiologia, Facultad de Medicina, UNAM, Mexico DF, Mexico 2Biologia de la Reproduccion, UAM-Iztapalapa, Mexico, DF, Mexico |
| Primary Theme and Topics |
Cognition and Behavior - Behavioral Pharmacology -- Other |
| Session: |
648. Behavioral pharmacology: other--sex and steroids Poster |
| Presentation Time: | Tuesday, November 13, 2001 4:00 PM-5:00 PM |
| Location: | Exhibit Hall VV-10 |
| Keywords: | ANANDAMIDE, CANNABINOIDS, LIPID, ACTIVITY |
Delta9-tetrahydrocannabinol and anandamide (ANA) are the vegetal and the animal marijuana, respectively. They promote overeating and affect sexual behavior. Oleamide (OLE) is an endogenous sleep-inducing lipid, with several cannabinoid-like properties. OLE effects on feeding and sexual behavior were evaluated and compared with those induced by ANA. Experiment 1. Food satiated male Wistar rats received intraperitoneal (i.p.) injections of OLE or ANA (0.5, 1.0, 2.0 and 4.0 mg/kg) or vehicle. Food intake was measured at 1, 2, and 3 hours following injection. Experiment 2. Male sexual behavior was evaluated in Wistar rats after the i.p. administration of OLE, ANA (doses as above) or vehicle. Experimental males were exposed to estrogenous + progesterone-induced receptive females, 15 min after the injection. Both food intake and sexual behavior tests were carried out during the first half of the dark phase. Results showed that all doses of OLE and ANA induced significant overeating, with only one exception, ANA (4.0 mg/kg). ANA, but not OLE interfered with the performance of masculine sexual behavior. These results suggest OLE may mimmic some cannabinoid activity.
Supported by Grant IN233199 DGAPA-UNAM to LN
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2001 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2001. Online.
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