Neuroscience 2005 Abstract
| Presentation Number: | 563.1 |
|---|---|
| Abstract Title: | Differential sensitivity to an acute cannabinoid agonist on GABA<sub>A</sub> receptor-mediated inhibitory neurotransmission in hippocampal CA1 area in slices from young and old rats. |
| Authors: |
Kang-Park, M.*1
; Moore, S. D.1,3
; Wilson, W. A.2,3
; Swartzwelder, H. S.1,3
1Psychiatry, Duke Univ. Med. Ctr., Durham, NC 2Pharmacology, Duke Univ. Med. Ctr., Durham, NC 3NC, room 25, building 16, DVAMC, 27705, |
| Primary Theme and Topics |
Disorders of the Nervous System - Addiction and Drugs of Abuse -- Cannabinoids |
| Secondary Theme and Topics | Neural Excitability, Synapses, and Glia: Cellular Mechanisms<br />- Ligand-Gated Ion Channels<br />-- GABAa receptors: Physiology |
| Session: |
563. Cannabinoids Poster |
| Presentation Time: | Monday, November 14, 2005 1:00 PM-2:00 PM |
| Location: | Washington Convention Center - Hall A-C, Board # UU80 |
| Keywords: | CANNABINOIDS, GABA, HIPPOCAMPUS, MEMORY |
The cannabinoid system in the hippocampus is thought to mediate impairment of learning and memory in marijuana users. To test the hypothesis that adolescents are more sensitive than adults to the acute effects of marijuana on hippocampal cannabinoid function, we examined the effects of the cannabinoid agonist WIN55,212-2 on GABA-A receptor mediated inhibitory neurotransmission in the CA1 hippocampal area. Hippocampal slices were prepared from adolescent (ages 28-33 days) or adult (ages 100-150 days) rats. GABA-A receptor-mediated synaptic currents were pharmacologically isolated and recorded using a whole-cell patch clamp configuration. The GABA-A receptor-mediated currents in slices from adolescent rats showed a significant 35% decrease in the presence of WIN55,212-2 (1 uM) (n=6, p <0.01). However, there was no significant effect of WIN55,212-2 on synaptic responses of neurons from adult rats (n=4, p=0.1). The difference between the two groups was significant (p=0.03, independent t-test). This result suggests that greater sensitivity to the inhibitory effects of cannabinoids on GABA-A receptor-mediated inhibition may underlie the greater sensitivity of adolescents to marijuana (specifically, delta9-tetrahydrocannabinol, THC)-induced memory impairment.
Supported by NIDA grant 1RO1-DA019346 (HSS) and VA Merit Reviews (SDM, WAW).
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005. Online.
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