Neuroscience 2000 Abstract
| Presentation Number: | 582.3 |
|---|---|
| Abstract Title: | Antioxidants prevent neurotoxicity in a binge-drinking model of alcoholism. |
| Authors: |
Hamelink, C. R.*2
; Hampson, A. J.1
; Axelrod, J.1
; Eskay, R. L.2
1Lab Cell.Molec.Regulation, NIMH, Bethesda, MD 2Sect. Neurochem. Neuroendocrinol., NIAAA, Bethesda, MD |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 143. Drugs of abuse: alcohol, barbiturates and benzodiazepines |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 141. Neurotoxicity |
| Session: |
582. Drugs of abuse: alcohol IV Poster |
| Presentation Time: | Tuesday, November 7, 2000 3:00 PM-4:00 PM |
| Location: | Hall G-J |
| Keywords: | Alcohol, CANNABINOIDS, Furosemide, Hippocampus |
Alcoholism causes neurological disorders such as memory loss and cognitive disfunction. Binge drinking, the repeated consumption of high levels of alcohol over a several day period, is a widespread form of alcoholism in society today. One of the mechanisms leading to alcohol-induced neurotoxicity appears to be oxidative stress. This study demonstrates that administration of antioxidants such as alpha tocopherol (Vitamin E), butylhydroxytoluene (BHT), and cannabidiol (CBD) significantly reduce neurotoxicity in the hippocampal-entorhinal complex of rats in a binge-type model of alcoholism. The diuretic furosemide has also been shown to prevent neurotoxicity in this model. The proposed mechanism of action was linked to the reduction of edema. Using the binge-model we compared furosemide with two similar compounds, bumetanide and L-644,711. L-644,711 has previously been shown to be protective in an edema-based model of brain injury. However, in the present study, furosemide was found to be neuroprotective while bumetanide and L-644,711 were not. Further investigations revealed that furosemide possessed antioxidant properties not found in the other compounds. These data demonstrate that antioxidants are effective neuroprotectants in a binge drinking model of alcoholism and suggest that furosemide protection may be more related to its antioxidant properties than its ability to reduce edema.
Supported by National Institutes of Health
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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