Neuroscience 2002 Abstract
| Presentation Number: | 577.24 |
|---|---|
| Abstract Title: | CANNABINOID RECEPTOR 1 (CB1) EXPRESSION INCREASES IN PONS AFTER REM SLEEP DEPRIVATION PLUS REBOUND. |
| Authors: |
Martinez-Vargas, M.*1
; Gonzalez-Rivera, R.1
; Mendez-Diaz, M.1
; Prospero-Garcia, O.1
; Navarro, L.1
1Phisiology, Fac. Medicina, UNAM, Mexico City, Mexico |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Attention |
| Session: |
577. Biological rhythms and sleep: animal studies II Poster |
| Presentation Time: | Tuesday, November 5, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 N-22 |
| Keywords: | sleep, stress, sleep-deprivation |
Effects of delta-9-THC, the most active of the psychoactive substances extracted from marijuana are mediated by cannabinoid receptors CB1R and CB2R. CB1R has a preferential distribution in central nervous system and may be mediating the marijuana effects on sleep, which include increase in subjective sleepiness, alpha waves in the EEG and slow wave sleep (SWS). We previously reported that sleep rebound after deprivation of total sleep increases CB1R expression. This study aims to analyze if this effect was mediated by Rapid eye movement sleep (REMS) or SWS deprivation. Twelve Wistar male rats were REMS deprivated using the flower pot for 24 hours (REMSD). Six of them were allowed to rebound for 2 hours (REMSD + R). As stress control, 11 rats were maintained 24 hours on a large platform (LP) and 5 were allowed to recover for 2 hours (LP + R). All rats were sacrificed at the same hour that control rats (n=6). Membrane enriched fractions of pons were analyzed by western blot using serum anti-CB1R. Results indicated that REMSD did not modified CB1R expression but it highly increased in pons of REMSD+R groups. Our data also indicate that CB1R expression increases in LP and LP+R groups. These data suggest an interaction between sleep and CB1R expression. They also suggest that stressful conditions increase CB1R expression, which agrees with a potential anxiolitic role of cannabinoids.
Supported by PAPIIT IN219201 given to LN
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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