Neuroscience 2000 Abstract
| Presentation Number: | 210.3 |
|---|---|
| Abstract Title: | Recovery of physiologic functions in carotid chemoreceptor denervated newborn rats. |
| Authors: |
Serra, A.*1
; Brozoski, D. T.1
; Franciosi, R.2
; Forster, H. V.1,4
; Hillard, C.3
1Physiology, Medical College of Wisconsin, Milwaukee, WI 2Pediatrics, Medical College of Wisconsin, Milwaukee, WI 3Pharmacology, Medical College of Wisconsin, Milwaukee, WI 4Zablocki VA Medical Center, Milwaukee, WI |
| Primary Theme and Topics |
E. Endocrine and Autonomic Regulation - 69. Respiratory regulation |
| Secondary Theme and Topics | A. Development and Regeneration<br />- 24. Developmental disorders |
| Session: |
210. Respiratory regulation: chemoreception I Slide |
| Presentation Time: | Monday, November 6, 2000 8:30 AM-8:45 AM |
| Location: | Room 383 |
| Keywords: | Carotid Body Denervation, Neonatal Rats, Chemoreceptor, Ventilation |
Carotid body denervation (CBD) in newborn rats produces high mortality and, in survivors, weight loss and severe breathing abnormalities. To gain insight into the recovery of physiologic functions in newborn Sprague-Dawley rats that survived CBD or sham-denervation (SHAM) at 6 different postnatal (PN) age-groups (PN 2-3, PN 4, PN 7-8, PN 12-13, PN 15 and PN 20-21), we studied the animals before and after surgery for 3-4 weeks in a plethysmograph during eupnea and tested the response to hypoxia (FIO2: 0.12) at 2 and 22 days after surgery. We found that CBD rats had an initial significant (P<0.05) decrease in weight gain at all ages except PN 20-21 (P=0.41) but resumed normal growth after a few days or a few weeks (PN12-13 and 15 or PN2-3, PN 4 and PN 7-8, respectively), while SHAM rats did not show any changes in weight gain. There was a greater inhibition of breathing during hypoxia in CBD rats 2 days after denervation than in SHAM. However, CBD and SHAM rats had similar responses to hypoxia 22 days after surgery. Venous (jugular) injections of NaCN produced nearly equal ventilatory responses in CBD and SHAM rats 3 weeks after denervation. There were ventilatory responses to aortic injections of NaCN in 2 of 3 CBD but in none of 4 SHAM rats, while carotid NaCN responses were present in SHAM but not in CBD rats. We conclude that newborn rats, which survive CBD, regain almost completely normal physiologic functions despite the loss of the carotid bodies.
Supported by SIDS Research Fund of WI, American Heart Association 9910088Z, NIH 25738 and Veterans Administration.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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