Neuroscience 2002 Abstract
| Presentation Number: | 172.2 |
|---|---|
| Abstract Title: | EFFECT OF CAROTID BODY DENERVATION AT VARIOUS POSTNATAL AGES ON CYTOCHROME OXIDASE ACTIVITY IN MEDULLARY RESPIRATORY NUCLEI OF RATS. |
| Authors: |
Liu, Q.*1
; Wong-Riley, M. T. T.1
1Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI |
| Primary Theme and Topics |
Autonomic, Limbic and Other Systems - Autonomic -- Respiratory regulation |
| Secondary Theme and Topics | Development<br />- Development of Sensory, Motor and Limbic Systems<br />-- Motor system |
| Session: |
172. Autonomic: respiratory regulation--afferents Poster |
| Presentation Time: | Sunday, November 3, 2002 2:00 PM-3:00 PM |
| Location: | Hall A2-B3 L-31 |
| Keywords: | DEVELOPMENT, BRAIN STEM NUCLEI, PRE-BOTZINGER COMPLEX , NEUROKININ 1 RECEPTOR |
Previously, we have shown that the pre-BÖzinger complex (PBC), presumed center of respiratory rhythmogenesis, exhibited reduced cytochrome oxidase (CO; a metabolic marker) activity at postnatal days (P) 3-4 and 12, with a concomitant decrease in glutamate and NMDAR1, and an increase in GABA, GABAB, GlyR and GluR2 (J Appl Physiol 92:923-34, 2002). We hypothesized that medullary respiratory nuclei would be more affected by carotid body denervation (CBD) during these two vulnerable windows than at other times. CBD and sham surgeries were performed on rats each day from P2 to P14 and on P21. After a 3-day survival, rats were perfused and their brain stems processed for CO and neurokinins 1 receptor. Our results indicate that: 1) CO activity of PBC, ventrolateral nucleus of solitary tract (NTSVL), nucleus ambiguus (NA), and inferior olivary nucleus (ION) in CBD animals was significantly lower than that of sham controls, especially when CBD was performed at P3 and P11; 2) CO activity in the spinal trigeminal nucleus (Sp5) of CBD animals showed a slight decrease as compared to sham, but there was not a greater decrease when CBD was done at P3 and P11; and 3) sham animals exhibited a 1-day delay in their metabolic development while CBD animals showed a 2-day delay. Our data suggest that CBD is more detrimental to the metabolic integrity of medullary respiratory nuclei, especially when induced around P3-4 and P12, the two vulnerable windows for postnatal development of brain stem respiratory nuclei in the rat. CBD also causes a developmental delay of these nuclei.
Supported by Children's Hospital Foundation, Milwaukee, WI
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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