Neuroscience 2000 Abstract
| Presentation Number: | 112.6 |
|---|---|
| Abstract Title: | Increased density of [<SUP>3</SUP>H]55,940 binding to the cannabinoid<SUB>1</SUB> receptor in the frontal cortex from subjects with schizophrenia. |
| Authors: |
Dean, B.*1
; Bradbury, R.1
; Scarr, E.1
; Pavey, G.1
; Sundram, S.1
; Copolov, D. L.1
1Div Molec Schizophrenia, Mental Hlth Res Inst, Parkville, Australia |
| Primary Theme and Topics |
J. Disorders of the Nervous System and Aging - 140. Neuropsychiatric disorders |
| Secondary Theme and Topics | D. Neurotransmitters, Modulators, Transporters, and Receptors<br />- 54. Cannabinoids |
| Session: |
112. Neuropsychiatric disorders: schizophrenia I Slide |
| Presentation Time: | Sunday, November 5, 2000 2:15 PM-2:30 PM |
| Location: | Room 388 |
| Keywords: | SCHIZOPHRENIA, CANNABINOIDS, POSTMORTEM, CORTEX** |
There is evidence that cannabis use is associated with an increased incidence of schizophrenia1 which raises the possibility that abnormalities in the cannabinoid system could be involved in the pathology of the illness. To begin to address this question we used in situ radioligand binding and autoradiography to measure [3H]CP 55,940 binding to the cannabinoid1 (CB1) receptor in the frontal cortex (FC), caudate-putamen (CP) and temporal lobe (TL) from 14 schizophrenic subjects and 14 non-schizophrenic subjects. To delineate between cannabis receptors [3H]CP 55,940 was displaced by 10μM SR 141716A, a CB1 receptor antagonist. Five schizophrenic subjects and 4 non-schizophrenic subjects had a history of cannabis use confirmed by the presence of plasma THC. The remaining subjects had no history of cannabis use and no plasma THC. Analysis of [3H]CP 55,940 using two way ANOVA showed that there was an increase in the density of radioligand binding in the FC from subjects with schizophrenia compared to that in non-schizpohrenic subjects (Mean±SEM: 143±9.9 vs 128±7.2 fmol / mg ETE; p<0.05) that was independent of THC use. In the CP there was an increase in the binding of [3H]CP 55,940 in subjects using THC compared to those who did not (140±10 vs 135±8 fmol / mg ETE,p<0.05) that was independent of diagnosis. There was no significant differences in binding associated with diagnosis or drug use in the TL. These data provide preliminary support to the hypothesis that changes in the endogenous cannabinoid system of the brain may play a role in the pathology of schizophrenia. 1. Andreasson, S. et al. (1987) Lancet ii; 1483-1485.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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