Neuroscience 2004 Abstract
| Presentation Number: | 47.12 |
|---|---|
| Abstract Title: | Leptin regulates endocannabinoid signaling in an appetite-related neural circuit. |
| Authors: |
Jo, Y.*1
; Chua, S. C.2
; Role, L. W.1
1Dept Anat & Cell Biol Ctr Neruobiol, Colum Univ Col Physi & Surg, New York, NY 2NY, 1051 Riverside Dr, 10032, |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Neurotransmitters -- Peptides |
| Secondary Theme and Topics | Homeostatic and Neuroendocrine Systems<br />- Regulation of Food Intake and Body Weight<br />-- Neuropeptide regulators |
| Session: |
47. Peptides I Poster |
| Presentation Time: | Saturday, October 23, 2004 4:00 PM-5:00 PM |
| Location: | San Diego Convention Center - Hall A-H, Board # I4 |
| Keywords: | OBESITY, RETROGRADE, FOOD INTAKE, REWARD |
Delta9(-)-tetrahydrocannabinol (THC) in marijuana as well as anandamide, an endogenous ligand for cannabinoid receptors, increases food intake and body weight (Cota et al., 2003a; Hao et al., 2000; Williams and Kirkham, 2002). Prior studies suggest that endogenous cannabinoids and their receptors are present in the lateral hypothalamic area (Cota et al., 2003b; Moldrich and Wenger, 2000). In addition, immunohistochemical and in situ hybridization studies demonstrated that leptin receptors are found within the LH (Elmquist et al., 1998; Hakansson et al., 1998). We examined the mechanism by which THC may stimulate appetite in studies of synaptic transmission within the LH. We examined endocannabinoid signaling and tested for effect of leptin on endocannabinoid signaling by comparing synapses in wild-type (+/+) lateral hypothalamic slices with slices obtained from leptin deficient (ob/ob) mice. Brief depolarization of postsynaptic neurons depressed GABAergic transmission in all mice independent of genotype. Leptin, as well as CB1 receptor antagonists, block this depolarization-induced suppression of inhibition (DSI). Consistent with endogenous regulation of cannabinoid signaling by leptin, the leptin-deficient, ob/ob mice exhibit a more prolonged DSI than observed in wild type mice. Our data provide a mechanism wherein endocannabinoid signaling and its regulation by leptin could modulate homeostatic circuits related to ingestive behavior and energy balance.
Supported by NS22061
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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