Neuroscience 2002 Abstract
| Presentation Number: | 783.16 |
|---|---|
| Abstract Title: | CANNABINOID CB1 ANTAGONISTS SUPPRESS FOOD INTAKE IN A VARIETY OF TASKS IN RATS. |
| Authors: |
McLaughlin, P. J.*1
; Wisniecki, A.1
; Tardiff, D. J.1
; Liu, Q.2
; Makriyannis, A.2
; Salamone, J. D.1
1Dept Psychol, University of Connecticut, Storrs, CT 2School of Pharmacy, University of Connecticut, Storrs, CT |
| Primary Theme and Topics |
Cognition and Behavior - Behavioral Pharmacology -- Other |
| Secondary Theme and Topics | Neurological and Psychiatric Conditions<br />- Addiction and Drugs of Abuse<br />-- Opioids and others |
| Session: |
783. Behavioral pharmacology V Poster |
| Presentation Time: | Wednesday, November 6, 2002 4:00 PM-5:00 PM |
| Location: | Hall A2-B3 P-25 |
| Keywords: | FEEDING, OPERANT, CANNABINOIDS, RAT |
CB1 agonists, including delta 9-tetrahydrocannabinol (the main psychoactive ingredient in marijuana), have been shown to increase feeding in rats and humans. Conversely, it has been reported that acute administration of CB1 antagonists reduces food intake in rats. Based upon this observation, it has been suggested that CB1 antagonists could be useful as appetite suppressant drugs. The present studies were designed to provide a detailed examination of the effects of CB1 antagonists on food intake across a broad range of paradigms. Two CB1 antagonists (AM 251 and SR 141716A) were administered to rats trained on two food-reinforced operant schedules (fixed ratio 1 and fixed ratio 5). Both drugs produced a dose-dependent decrease in lever pressing, with little evidence of motor slowing as defined by analyses of the interresponse time distributions. To characterize further the putative appetite suppression produced by these compounds, the effects of AM251 and SR141716A on feeding behavior were assessed using diets of differing macronutrient composition (high-fat vs. high-carbohydrate vs. lab chow). Intake of all food types was significantly reduced by CB1 antagonism, but this effect was more pronounced with the more palatable high-fat and high-carbohydrate diets. These findings support the hypothesis that CB1 antagonists could be useful for the suppression of appetite, and suggest that these drugs could be particularly effective for the suppression of intake of palatable foods.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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