Neuroscience 2002 Abstract
| Presentation Number: | 738.5 |
|---|---|
| Abstract Title: | CO-EXPRESSION OF CB1 AND 5 HT3 RECEPTORS IN RAT DORSAL ROOT GANGLIA. |
| Authors: |
Diaz-Ruiz, O.*1
; Morales, M.1
1Cellular Neurophysiology, NIDA-IRP, Baltimore, MD |
| Primary Theme and Topics |
Synaptic Transmission and Excitability - Neurotransmitters -- Cannabinoids |
| Secondary Theme and Topics | Synaptic Transmission and Excitability<br />- Neurotransmitters<br />-- Serotonin |
| Session: |
738. Neurotransmitters: cannabinoids II Poster |
| Presentation Time: | Wednesday, November 6, 2002 1:00 PM-2:00 PM |
| Location: | Hall A2-B3 C-58 |
| Keywords: | spinal cord, pain |
The type three serotonin (5-HT3) receptor is the only ion channel receptor for serotonin. This receptor modulates visceral afferent information and visceral reflexes, participates in nociception, cognition, and has been suggested to play a role in the biology of drugs of abuse. The central CB1 cannabinoid receptor is a G-protein-coupled receptor that mediates the effects of the major psychoactive constituent of marijuana, delta 9-tetrahydrocannabinol. In recent studies, we demonstrated that 5-HT3 and CB1 receptors are co-expressed in many neurons throughout the central nervous system (CNS) (Morales and Backman, 2002; Morales et al., 2002). Experimental animal studies and clinical observations indicate that antagonists of the 5-HT3 receptor and agonists of the CB1 receptor have analgesic and antiemetic properties, suggesting overlap of these receptors at the functional level. As 5-HT3 and CB1 receptors are expressed in the peripheral nervous system (PNS), we investigated whether they coexist in neurons of the dorsal root ganglia (DRG) and nodose ganglia. Towards this end, we used double in situ hybridization histochemistry. We determined that contrary to findings in the CNS, only a small population of CB1 expressing neurons (7. 1 ± 2%) contains 5-HT3A mRNA in DRG. Similarly, only a small proportion of 5-HT3A expressing neurons (5. 6 ± 1.2%) have CB1 transcripts. These results suggest that analgesic and perhaps antiemetic effects of 5-HT3 antagonists and CB1 agonists are not mediated by functional properties due to the co-existence of both receptors at the cellular level.
Supported by Intramural Research Program, NIDA/NIH.
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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