Neuroscience 2003 Abstract
| Presentation Number: | 622.8 |
|---|---|
| Abstract Title: | Effects of cannabinoids on extinction of place preference learning. |
| Authors: |
Burton, D. P.*1
; Parker, L. A.2
1Section Biopsychology, Univ. of Toronto, Toronto, Canada 2ON, 250 Col. St, M5T 1R8, |
| Primary Theme and Topics |
Cognition and Behavior - Animal Cognition and Behavior -- Emotional learning & memory systems and modulation of memory |
| Session: |
622. Animal Cognition and Behavior: Learning I Poster |
| Presentation Time: | Tuesday, November 11, 2003 11:00 AM-12:00 PM |
| Location: | Morial Convention Center - Hall F-I, Board # V11 |
| Keywords: | Cannabidiol, delta-9-tetrahydrocannabinol, Reward, Addiction |
Recent evidence suggests that CB1 knockout mice display impaired extinction of Pavlovian fear conditioning. We explored the potential of low doses of the two principle components of marijuana, the psychoactive cannabinoid, delta-9-tetrahydrocannabinol (THC), and the non-psychoactive cannabinoid, cannibidiol (CBD), to modulate the extinction of amphetamine- and cocaine-induced place preference learning. Both cannabinoids potentiated extinction of place conditioning without producing conditioning on their own. At the doses employed neither drug modified the establishment or the expression of amphetamine-induced place preference learning. Our results support previous reports that the endogenous cannabinoid system plays a role in the modulation of extinction.
Supported by NSERC
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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