Neuroscience 2000 Abstract
| Presentation Number: | 653.15 |
|---|---|
| Abstract Title: | The medial prefrontal cortex is involved in the effects of abused drugs on spatial working memory. |
| Authors: |
Nakamura-Palacios, E. M.*1
; Oliveira, R. W. D.1
; Ferreira, J. T. C.1
; Melo, L. C. S.1
; Laranja, L. R.1
; Lugon, M. B.1
; Curi, E. F.1
1Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil |
| Primary Theme and Topics |
I. Neural Basis of Behavior - 109. Learning and memory: pharmacology |
| Secondary Theme and Topics | J. Disorders of the Nervous System and Aging<br />- 146. Drugs of abuse: opioids and others |
| Session: |
653. Learning and memory: pharmacology--spatial memory Poster |
| Presentation Time: | Wednesday, November 8, 2000 10:00 AM-11:00 AM |
| Location: | Hall G-J |
| Keywords: | Medial Prefrontal Cortex, Abused Drugs, Spatial Working Memory, 8-Arm Radial Maze |
The prefrontal cortex (PFC) is a site for working memory and part of a brain reward circuit. Our studies examined the involvement of the medial PFC (mPFC) in the effects of abused drugs such as alcohol (ETOH), cocaine (COC) or Δ9-tetrahydrocannabinol (Δ9-THC) on the performance of 5-s, 1-h or 4-h delayed tasks in an 8-arm radial maze. Male Wistar rats (250 - 300 g) with bilateral cannulas implanted in the mPFC (B: 2.5 mm A, +/- 1 mm L, 2.7 mm V) received intraperitoneal (IP, 5 min for ETOH or COC or 30 min before session for Δ9-THC) or intracortical [IC, 5 min for ETOH, COC or Δ9-THC or 15 min before session for naltrexone (NTX) or haloperidol(HAL)] drug administration. ETOH IC (32 - 180 μg) disrupted 5-s and 1-h delay performance in a dose-dependent manner, whereas ETOH IP (0.18 - 1.8 g/kg) tended to impair the performance of 1-h delayed task. The disruptive effects of ETOH IC (100 μg) on 1-h delayed task was blocked by NTX IC (56 μg). COC IP (1 - 18 mg/kg) impaired 5-s and 1-h delay performance in a dose-dependent manner whereas COC IC (10 - 100 μg) tended to decrease the number of errors in the 1-h delay task. The facilitating effect of COC IC (32 μg) was particularly evident in the performance of a 4-h delay task and was attenuated by HAL IC (32 μg). Both Δ9-THC IP (0.32 - 1.8 mg/kg) or IC (32 - 180 μg) impaired the performance of 1-h delay task in a dose-dependent manner. These results suggest that the mPFC is involved in the disruptive effects of alcohol or Δ9-tetrahydrocannabinol, or in the facilitanting effect of cocaine on spatial working memory.
Supported by FACITEC, CNPq, CAPES, PRPPG-UFES
Sample Citation:
[Authors]. [Abstract Title]. Program No. XXX.XX. 2000 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2000. Online.
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