Dysregulation of mRNA Localization and Translation in Genetic Disease - Gary J. Bassell
Gary J Bassell, PhD
Eric Wang, PhD
University of Florida
Date & Time: Sunday, November 13, 2016 1:30pm - 4pm
This minisymposium will highlight recent discoveries on molecular mechanisms of mRNA localization and translation, the dysregulation of mRNA in genetic diseases, and therapeutic strategies. The session integrates diverse topics and mechanisms, including the roles of several mRNA binding proteins in axonal growth, synapse development, synaptic function, learning, and memory. Mechanisms of neurodevelopmental, neuropsychiatric, and neurodegenerative diseases will be discussed. Diverse approaches include use of genome-wide transcriptomics, super-resolution microscopy, animal models, human patient cells, and postmortem tissue.