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Neuroscience 2003 Abstract
| Presentation Number: |
173.4 |
| Abstract Title: |
Synchrony of firing in coupled pairs of inhibitory interneurons of neocortex. |
| Authors: |
Mancilla, J. G.*1;
Lewis, T. J.;
Pinto, D. J.1;
Rinzel, J.;
Connors, B. W.1
1Neurosci., Brown Univ., Providence, RI
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| Primary Theme and Topics |
Sensory Systems
- Tactile/Somatosensory
-- Cortex and thalamocortical relationships
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| Session: |
173. Somatosensory Cortical Circuitry
Poster |
| Presentation Time: |
Sunday November 9, 2003 11:00 AM-12:00 PM |
| Location: |
Convention Center Exhibit Hall, Poster Board G91 |
| Keywords: |
BARREL, MODELING, SOMATOSENSORY CORTEX, FREQUENCY
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The barrel cortex of rodents has two networks of inhibitory interneurons, fast-spiking (FS) and low-threshold spiking (LTS); cells within each network are electrically coupled to one another. Our theoretical studies suggest that the strength of electrical coupling and the frequency of spiking are two important determinants of synchrony. We examined the frequency-dependence of synchrony for connected pairs of FS or LTS cells with electrical coupling, chemical inhibitory connections, or a combination of both. In some unconnected pairs, connections were simulated using a dynamic clamp protocol to test a range of connection strengths. The dependence of synchrony on firing frequency was tested by either increasing the frequency of both cells continuously, with simultaneously injected current ramps, or stepwise with simultaneous current steps. In both cases, running cross-correlograms indicated that synchrony increased as electrical coupling strength increased. For current ramps, the range of frequencies over which pairs fired within 0.5 Hz of each other (frequency locking) increased with increasing coupling strength. Pairs with inhibitory connections showed less synchrony at low frequencies, consistent with modeling studies, and less frequency locking. To test the robustness of synchrony we held firing frequency of one neuron constant while ramping or stepping frequency in a connected cell. The frequency difference over which synchrony could be maintained increased with coupling strength. Our results indicate that at all frequencies tested (FS cells 20-90 Hz; LTS cells 5-30 Hz) electrical coupling synchronizes firing in interneurons, while inhibition tends to desynchronize firing at low frequencies (20-40 Hz) but facilitates synchrony at high frequencies (60-90 Hz).
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| Supported by NIH and the Epilepsy Foundation through the support of the American Epilepsy Society and Milken Family Foundation. |
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| Sample Citation: |
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[Authors]. [Abstract Title]. Program No. XXX.XX. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience, 2003. Online.
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| Copyright © 2003-2010 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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