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Neuroscience 2004 Abstract
| Presentation Number: |
977.7 |
| Abstract Title: |
Phase-locking in pairs of neocortical fast-spiking interneurons promoted by inhibitory synapses. |
| Authors: |
Mancilla, J. G.*1;
Lewis, T. J.2;
Rinzel, J.2;
Connors, B. W.1
1Dept Neurosci., Brown Univ., Providence, RI
2NY, Box 1953, 02912,
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| Primary Theme and Topics |
Sensory Systems
- Tactile/Somatosensory
-- Barrels
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| Session: |
977. Barrels II
Poster |
| Presentation Time: |
Wednesday October 27, 2004 3:00 PM-4:00 PM |
| Location: |
Convention Center Exhibit Hall, Poster Board Y11 |
| Keywords: |
barrels, synchrony, electrical coupling, oscillator
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Fast-spiking (FS) inhibitory interneurons in the barrel cortex of rodents are connected to other FS cells by electrical coupling and/or inhibitory synapses. Our theoretical studies suggest that the phase-difference at which pairs of interneurons will lock is determined by the relative contribution of electrical coupling and inhibition, as well as the speed and duration of the IPSPs. In a thalamocortical slice preparation, we examined the frequency-dependence of phase-locking for pairs of cortical FS cells connected by chemical inhibition alone or a combination of both electrical coupling and inhibition. In some unconnected pairs, connections were simulated using dynamic clamp. In cells that were connected only by naturally occurring inhibitory synapses, anti-phase activity was observed at low frequencies (< 50 Hz) and synchrony was found at higher frequencies. At the transition frequency, there was a region of bistability. However, phase-locking with natural inhibition alone was often weak. Changing the shape of simulated inhibitory postsynaptic conductances (IPSGs) using dynamic clamp indicated that fast, narrow IPSGs promote anti-synchrony while slow, wide IPSGs promote synchrony. When cells were connected by both weak electrical coupling and inhibition, the inhibition reinforced the synchronizing property of electrical coupling at high frequencies and promoted bistability at low frequencies. When electrical coupling was strong, pairs exhibited synchrony at all frequencies regardless of the inhibition. However, strongly coupled cells could be forced into anti-phase only when inhibition was present, suggesting a role for inhibition.
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| Supported by NIH. T.J. Lewis supported by fellowship # F32 MH12873 |
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| Sample Citation: |
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[Authors]. [Abstract Title]. Program No. XXX.XX. 2004 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2004. Online.
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| Copyright © 2004-2010 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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