| Presentation Number: |
840.13 |
| Abstract Title: |
FIRING DYNAMICS OF SINGLE AND COUPLED PAIRS OF INHIBITORY INTERNEURONS IN NEOCORTEX. |
| Authors: |
Mancilla, J. G.*1;
Lewis, T.2;
Pinto, D. J.1;
Rinzel, J.2;
Connors, B. W.1
1Dept of Neurosci, Brown Univ, Providence, RI
2Center for Neural Science, New York Univ, NY, NY
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| Primary Theme and Topics |
Sensory Systems
- Tactile/Somatosensory
-- Cortex and thalamocortical relationships
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| Session: |
840. Tactile/somatosensory: cortex and thalamocortical interactions II
Poster |
| Presentation Time: |
Thursday November 7, 2002 8:00 AM-9:00 AM |
| Location: |
Convention Center Exhibit Hall, Poster Board D-102 |
| Keywords: |
OSCILLATION, SYNCHRONY, GAP JUNCTION, BARREL
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Neocortical inhibitory neurons are synaptically connected and comprise at least two electrically coupled networks of fast-spiking (FS) and low-threshold spiking (LTS) neurons. Theoretical studies on integrate-and-fire neuron pairs suggest that the same level of activation can evoke phase-locked or uncorrelated activity depending on connection type and on recent firing history. We examine firing dynamics in real and simulated interneurons and their dependence on the neurons' intrinsic properties, connections, and firing history. Whole-cell recordings were obtained from rat cortical slices in vitro; simulations were run on a conductance-based model of FS neurons. Frequency curves and running cross-correlograms were constructed in response to increasing and then decreasing ramps of current. Frequency curves from both real and simulated individual neurons were asymmetric; firing onset occurred at a higher frequency than firing offset. Simulated FS pairs with electrical and/or fast inhibitory synaptic connections switch from anti-phase to in-phase firing at low vs. high frequencies; transitions occur at a higher frequency on the increasing vs. decreasing ramp. Real pairs of either FS or LTS neurons with synaptic interconnections switch from phase-locked to uncorrelated firing; transitions occur at different frequencies on the two ramps. Electrically coupled pairs also show frequency dependence, but are synchronous over a wider range of frequencies. These results suggest that the history-dependence of network activity can derive from both the history-dependence of individual neurons and from dynamics contributed by network connections.
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| Supported by NIH |
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| Sample Citation: |
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[Authors]. [Abstract Title]. Program No. XXX.XX. 2002 Neuroscience Meeting Planner. Orlando, FL: Society for Neuroscience, 2002. Online.
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| Copyright © 2002-2010 Society for Neuroscience; all rights reserved. Permission to republish any abstract or part of any abstract in any form must be obtained in writing by SfN office prior to publication.
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