Career Tools and Resources

2011 Short Course III

BACs, TRAPs, and Targeted Mutations: Revealing Secrets of the Mammalian Brain Using Advanced Genetic Approaches

Organizer: Nathaniel Heintz, PhD, Rockefeller University, Howard Hughes Medical Institute

Contributors: David D. Ginty, PhD, Department of Neuroscience, Johns Hopkins University School of Medicine; Stephen Hitchcock, PhD, Envoy Therapeutics; Ines Ibanez-Tallon, PhD, Department of Molecular Neurobiology, Max-Delbrück Center for Molecular Medicine, Berlin; Botond Roska, PhD, MD, Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research; Fekrije Selimi, PhD, Center for Interdisciplinary Research in Biology, Collège de France; Huda Y. Zoghbi, MD, Baylor College of Medicine, Howard Hughes Medical Institute, Jan and Dan Duncan Neurological Research Institute.

Although classical histological studies established that the morphology of specific neural cell types in the mammalian brain varies dramatically, the ability to genetically target these cell types and understand the biochemical basis of their structure and function eluded scientists for nearly a century. To address this problem, a variety of novel approaches have been developed for the investigation of genes, cells, and circuits in vivo. This day-long course consists of a series of lectures by the faculty illustrating the power of cell-specific genetic strategies for investigation of mechanisms that contribute to the histological and functional complexities of the mammalian brain, followed by informal breakout sessions, and includes a syllabus book.

Syllabus Content

Introduction (PDF)

Considerations for Target Selection in CNS Drug Discovery Programs (PDF)
Stephen A. Hitchcock, PhD

Molecular Dissection of Neural Circuits Controlling Nicotine Aversion (PDF)
Silke Frahm, PhD; Marta A. Slimak, Julio Santos-Torres, PhD; Beatriz Antolin-Fontes; Sebastian Auer, PhD; and Inés Ibañez-Tallon, PhD

Cell Types, Circuits, and Computation (PDF)
Rava Azeredo da Silveira, PhD and Botond Roska, PhD, MD

Proteomic Studies of a Single CNS Synapse Type: The Parallel Fiber/Purkinje Cell Synapse (PDF)
Fekrije Selimi, PhD; Ileana M. Cristea, PhD; Elizabeth Heller, PhD; Brian T. Chait, PhD; and Nathaniel Heintz, PhD

Molecular Identification of Rapidly Adapting Mechanoreceptors and Their Developmental Dependence on Ret Signaling (PDF)
Wenqin Luo, MD, PhD; Hideki Enomoto, MD, PhD; Frank L. Rice, PhD; Jeffrey Milbrandt, MD, PhD; and David D. Ginty, PhD

Regional Rescue of SCA1 Phenotypes by 14-3-3e Haploinsufficiency in Mice Underscores Complex Pathogenicity in Neurodegeneration (PDF)
Paymaan Jafar-Nejad, MD; Christopher S. Ward; Ronald Richman, BS; Harry T. Orr, PhD; and Huda Y. Zoghbi, MD

Download entire Short Course III syllabus (PDF)

Events Calendar

Nov 11 - 14, 2018
International Covention Centre
Sydney, Australia
Nov 8 - 11, 2018
Sheraton Grand at Wild Horse Pass
Arizona
Nov 11 - 14, 2018
International Covention Centre
Sydney, Australia
Nov 8 - 11, 2018
Sheraton Grand at Wild Horse Pass
Arizona
Jul 7 - 11, 2018
The German Neuroscience Society
Berlin, Germany